In vitro impacts of CPT derivatives on DCs. (A) Chemical structures of the 4 tested CPT derivatives are shown. Compound 3667-7B was decoded to be CPT-Na. (B) BM-DCs were incubated for 24 hours with each CPT derivative at 1 μM or vehicle alone and then examined for the surface expression of MHC II, CD40, and CD80 and for cell viability by PI uptake (mean ± SD; n = 3). Asterisks indicate statistically significant (*P < .05, **P < .01) increases compared with vehicle-treated controls.