Gene silencing in HuH7 cells. (A) F7 RNA expression after silencing REEP3, (B) FVII protein levels in cell media after silencing REEP3, (C) F7 RNA expression after silencing JAZF1, and (D) FVII protein levels in cell media after silencing JAZF1. *P = .01-.05; ***P < .001. Error bars indicate ±1 SD.