Mutational landscape and clonal heterogeneity of RAS/RTK signaling genes. (A) Mutational landscape showing patients with mutations in RAS/RTK pathway (right panel). The mutation frequency of each gene is shown (left panel). (B) VAFs of RAS/RTK pathway mutations with evidence for clonal heterogeneity for 3 illustrative patients. (C) VAFs of RAS/RTK pathway mutations without evidence for clonal heterogeneity. Clonality prediction was determined using the Pearson Goodness-of-Fit Test.