Figure 7.
Morphologic clearance of dysplastic features at the time of complete remission and NPM1 mutation clearance. (A) Pretreatment BM from a patient with MDS-EB with NPM1 mutation. Dysplastic erythroblasts (arrows) and granulocytes with increased blasts (arrowhead) are observed. (B) Dysplastic megakaryocytes (arrows) within a hypercellular BM. (C-D) Posttreatment BM of the same patient at the time of mutation clearance demonstrates clearance of blasts and regenerating hematopoietic cells without dysplastic changes. Original magnification ×500; Wright-Giemsa (A,C) and hematoxylin and eosin (B,D) stains.