Characteristics of mutations detected in patient samples. (A) Spectrum of mutations detected across all patients in the study (N = 283). (B) Comparison of mutations detected in those with a diagnostic BM sample (n = 142) vs a nondiagnostic BM sample (n = 65). (C) Distribution of the number of mutations according to final diagnostic category. “Other” denotes those patients with an alternative hematological malignancy.