Estimated differences in clinician- and patient-perceived changes in joint/fascia manifestations according to response categories defined by 2014 NIH algorithm and refined algorithm. Estimated differences in clinician- or patient-perceived 0-to-8 changes were calculated using linear mixed models with random patient effect in the respective comparisons. For example, estimated difference among improved patients according to the 2014 NIH algorithm compared with stable patients according to the same algorithm is shown in top left. Analysis was stratified by case type (incident [red; enrollment <3 months after chronic GVHD diagnosis] or prevalent [blue; enrollment ≥3 months after chronic GVHD diagnosis but within 3 years after transplantation]). Squares and diamonds indicate point estimates, and bars indicate 95% confidence intervals.