The protein profile of Cdx4 overexpressing HSPCs resembles the protein signature of immature erythroid stages. (A) Venn diagram representing the overlap of liquid chromatography-MS–based proteomics data (expressed proteins) to the published protein clusters, cluster 1 and cluster 2, derived from primitive stages of erythroid development.²⁸  (B) Gene variants represented in a matrix plot found in 3 mice indicating 34 genes that were also found in patients with AEL.⁵  The 3 genes marked on top of the list were recurrently mutated (>2 patients) in patients with AEL.⁵