Clonal dynamics and selective pressure of NT5C2 and TP53 mutations. (A) Graphs indicate the variant allele frequencies in the SNVs in NT5C2 as detected by whole-exome sequencing (supplemental Table 9). Patient identifiers (UPN) as well as amino acid exchanges are indicated. Below each graph, the results of the amplicon sequencing (AS) are indicated. (B) SNVs detected in TP53 (also supplemental Table 10). The Li-Fraumeni patient (590) is not shown.