Figure 1
Figure 1. Mechanisms of BCR-ABL activity in CML and blast crisis, leading to stimulation of proliferation and to induction of genetic instability, DNA damage, and impaired DNA repair. Reactive oxygen species induced by BCR-ABL are thought to mediate DNA damage and genetic instability. Data are from Skorski,34 Melo and Barnes,31 Radich,32 and Perrotti et al.33

Mechanisms of BCR-ABL activity in CML and blast crisis, leading to stimulation of proliferation and to induction of genetic instability, DNA damage, and impaired DNA repair. Reactive oxygen species induced by BCR-ABL are thought to mediate DNA damage and genetic instability. Data are from Skorski,34  Melo and Barnes,31  Radich,32  and Perrotti et al.33 

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