Tissue-specific depletion of CSF1R-EGFP⁺ resident tissue macrophages with anti-CSF1R antibody. MacGreen mice were treated with 400 μg of anti-CSF1R or control antibody (rat IgG) administered by IP injection, thrice weekly for 3 weeks. Shown are fluorescent micrographs of 12-μm sections of brain tissue showing parenchyma (A) and meninges (B), and of retina (C), lung (D), ovary (E), and uterus (F), from anti-CSF1R or rat IgG-treated mice. All images are 20× magnification.