Anti-CSF1R antibody mediated depletion of CSF1R-EGFP⁺ tissue macrophages. MacGreen mice were treated with 400 μg of anti-CSF1R or control antibody (rat IgG) administered by intraperitoneal injection, thrice weekly for 3 weeks. Fluorescent micrographs comparing EGFP expression in 12-μm sections of liver (A), skin (B), small intestine (C), colon (D), bladder (E), pancreas (F), testis (G), and kidney (H) from anti-CSF1R or rat IgG-treated mice are shown. All images are 20× magnification.