Figure 2
Figure 2. Phenotypic analysis of BCR/ABL-mediated B-ALL. Representative analysis for recipients of p210BCR/ABL expressing Lin− cells from a p19ARF-null background. Animals were killed approximately 2 to 3 weeks after transplantation when there were significant signs of illness. Leukocytes from bone marrow and spleen of naive control (CTL) recipient mice were harvested for flow cytometric lineage analysis. FACS plots show comparison of (A) the expression of B220, IgM, and (B) the expression of AA4.1, CD19 between CTL mice, EGFP+ and EGFP− populations of recipient mice. The gates in panel A separate IgMhi and IgMlo∼neg expressing B cells.

Phenotypic analysis of BCR/ABL-mediated B-ALL. Representative analysis for recipients of p210BCR/ABL expressing Lin− cells from a p19ARF-null background. Animals were killed approximately 2 to 3 weeks after transplantation when there were significant signs of illness. Leukocytes from bone marrow and spleen of naive control (CTL) recipient mice were harvested for flow cytometric lineage analysis. FACS plots show comparison of (A) the expression of B220, IgM, and (B) the expression of AA4.1, CD19 between CTL mice, EGFP+ and EGFP− populations of recipient mice. The gates in panel A separate IgMhi and IgMlo∼neg expressing B cells.

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