In vivo virulence of K pneumoniae in a peritonitis/sepsis model in wild-type (+/+) and serglycin knockout (−/−) mice. Mice were challenged with K pneumoniae intraperitoneally at 0 hours. Six animals from each genotype were killed at 1 hour and 5 hours after bacterial injection, and CFU counts were determined for blood and peritoneal fluid (perit) samples for each time point (1 and 5). Gray line shows the median; ♦, single experiments; *, statistically significant difference at the 5% level, Mann-Whitney nonparametric test.