Increased lymph flow from the ear in K14-VEGF-C and K14-VEGF-D Tg mice. (A-C) Evans blue dye was intradermally injected into the ear of untreated or inflamed K14-VEGF-C, K14-VEGF-D Tg, and wild-type mice and was extracted 16 hours after the dye injection. The total dye remaining in the ear skin is indicated. Representative pictures before Evans blue extraction are shown at the bottom. (A) Untreated K14-VEGF-C (n = 5) and K14-VEGF-D (n = 5) Tg mice had significantly less Evans blue remaining in their ear skin 16 hours after injection compared with wild-type mice (n = 10). (B) Evans blue was also injected 32 hours after UVB irradiation and extracted 16 hours later. UVB irradiated K14-VEGF-C (n = 5) and K14-VEGF-D (n = 4) Tg mice showed a faster lymph flow than irradiated wild-type mice (n = 10). (C) There was no difference in Evans blue clearance from the inflamed ear during acute inflammation after oxazolone challenge between all mice (wild-type, n = 10; K14-VEGF-C, n = 5; K14-VEGF-D, n = 5). Data are mean ± SD. *P ≤ .05 versus wild-type mice. **P ≤ .01 versus wild-type mice. ***P ≤ .001 versus wild-type mice.