Susceptibility plotted against age in the substantia nigra (SN) of SCD patients and controls from supplemental Figure 2 in the article by Miao et al that begins on page 1618 with the best-fit line (broken; left y-axis). Cumulative prevalence of silent cerebral infarction with age in children and young adults with SCD from Figure 1 in the article by Kassim et al⁴  with the best-fit line (unbroken; right y-axis). Courtesy of Xin Miao, John C. Wood, and Mark Rodeghier.