Figure 5.
Figure 5. Global transcriptional changes in CDKO relative to control HSCs after acute Nr4a1/3 codepletion. (A) Heat map of differentially expressed (P < .05 and fold change greater than 1.5 or less than −1.5) genes in CDKO relative to control HSCs (LSK CD48−CD150+) at 4 days after tamoxifen treatment. HSCs were sorted from 3 pools of bone marrow from control and CDKO mice (5 mice per pool) and subjected to RNA-seq. (B) Gene set enrichment analysis using the “Curated Pathways” gene sets as reference database. (C) Gene set enrichment analysis using the “Hallmarks of Cancer” gene sets. FDR, false discovery rate; NES, normalized enrichment score.

Global transcriptional changes in CDKO relative to control HSCs after acute Nr4a1/3 codepletion. (A) Heat map of differentially expressed (P < .05 and fold change greater than 1.5 or less than −1.5) genes in CDKO relative to control HSCs (LSK CD48−CD150+) at 4 days after tamoxifen treatment. HSCs were sorted from 3 pools of bone marrow from control and CDKO mice (5 mice per pool) and subjected to RNA-seq. (B) Gene set enrichment analysis using the “Curated Pathways” gene sets as reference database. (C) Gene set enrichment analysis using the “Hallmarks of Cancer” gene sets. FDR, false discovery rate; NES, normalized enrichment score.

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