Association of neutral evolutionary dynamic with IgH translocations in Myeloma XI and CoMMpass studies. Violin plot of the neutral evolutionary dynamics measured by R² (A) Myeloma XI and (B) CoMMpass. The distribution shows kernel density estimation, where a broader shape represents a higher probability of a value. The thick black bar represents the interquartile range. The thin line represents the 95% confidence interval. The dotted line corresponds to the R² = 0.98 threshold for discriminating neutral from nonneutral tumors. Statistical differences between experimental groups were evaluated by Wilcoxon rank-sum test. P < .05 was considered statistically significant.