DNA methylation at CAGE enhancers is correlated with survival in CN-AML. (A-C) Variably methylated CpG probes (A) cg11334730, (B) cg20281962, and (C) cg14484844) that occur in CAGE enhancer regions in CN-AML patients. Each example showing (from left to right) Kaplan-Meier curves, DNA methylation plots, and active histone mark ChIP-seq profiles for 1 normal CD34⁺ and 4 independent CN-AML patients. CN-AML patients were categorized into low (β <0.2), intermediate (0.2 < β<0.8), or high (β >0.8) DNA methylation subcategories. Statistical significance was determined by using the log-rank test. DNA methylation levels are plotted against mature and progenitor cells. Active histone marks are displayed for the surrounding area for each probe marked with a gray vertical line.