The majority of enhancer DMCs are independent of somatic mutations. DMCs have been tested by comparing either the total CN-AML cohort to normal bone marrow (NBM) progenitors or mutated vs wild-type CN-AML patients. Supervised hierarchical clustering was performed on enhancer DMCs (in rows), whereas individual samples were clustered unsupervised (in columns). Each mutation has been tested separately among CN-AML patients, and the heat map shows mutation-related enhancer DMCs as being mutually exclusive from enhancer DMCs of general CN-AML. The color key provides the mutational status of each patient. M-value of each DMC probe is color-coded for density (blue to red). N.A., not analyzed.