Figure 3.
Figure 3. Emerging GATA factor-dependent mechanistic circuits. (A) Ras-MAPK signaling controls GATA-2 activity.123 (B) GATA-2-GPR65 circuit negatively regulates hematopoiesis.127 (C) GATA-1-heme circuit regulates erythroid differentiation.134 (D) GATA-1-FoxO3-exosome circuit controls erythroid maturation.146,148 FFL, feed forward loop.

Emerging GATA factor-dependent mechanistic circuits. (A) Ras-MAPK signaling controls GATA-2 activity.123  (B) GATA-2-GPR65 circuit negatively regulates hematopoiesis.127  (C) GATA-1-heme circuit regulates erythroid differentiation.134  (D) GATA-1-FoxO3-exosome circuit controls erythroid maturation.146,148  FFL, feed forward loop.

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