Responses and mutations affecting candidate genes detected in tumor or liquid biopsies. (A) This waterfall plot shows the magnitude of response calculated as percent change relative to baseline. *Patients who progressed early and did not have a response assessment. (B) Mutations detected using a combination of exome and targeted sequencing are shown for the HME genes and additional genes of interest (MYD88, STAT6, and FAS). Patients are shown with those demonstrating a sustained response on the right and are in the same order as those in (A). For 4 patients (indicated with an asterisk), plasma was used as the sole source of tumor DNA for mutation detection.