Figure 3
Figure 3. Suggested treatment protocol for recurrent DVT during anticoagulant treatment. aLMWH once or twice daily at therapeutic dose together with a VKA (target INR, 2.0-3.0) and continue LMWH until a stable INR has been reached, but for a minimum of 5 days; bapixaban 10 mg twice daily for 1 week followed by 5 mg twice daily; rivaroxaban 15 mg twice daily for 3 weeks followed by 20 mg once daily; LMWH once or twice daily at therapeutic dose for at least 5 days followed by 150 mg dabigatran twice daily or by 60 mg edoxaban once daily; c10 mg vitamin K orally or IV; dLMWH dose increase by ∼25%; eLMWH once or twice daily at therapeutic dose together with a VKA (target INR, 2.5-4.0) and continue LMWH until a stable INR has been reached, but for a minimum of 5 days; fLMWH once or twice daily at therapeutic dose together with a VKA (target INR, 2.0-3.0) and aspirin (100 mg once daily), and continue LMWH until a stable INR has been reached but for a minimum of 5 days; gLMWH once or twice daily at therapeutic dose; and hfondaparinux weight-adjusted at a therapeutic dose.

Suggested treatment protocol for recurrent DVT during anticoagulant treatment.aLMWH once or twice daily at therapeutic dose together with a VKA (target INR, 2.0-3.0) and continue LMWH until a stable INR has been reached, but for a minimum of 5 days; bapixaban 10 mg twice daily for 1 week followed by 5 mg twice daily; rivaroxaban 15 mg twice daily for 3 weeks followed by 20 mg once daily; LMWH once or twice daily at therapeutic dose for at least 5 days followed by 150 mg dabigatran twice daily or by 60 mg edoxaban once daily; c10 mg vitamin K orally or IV; dLMWH dose increase by ∼25%; eLMWH once or twice daily at therapeutic dose together with a VKA (target INR, 2.5-4.0) and continue LMWH until a stable INR has been reached, but for a minimum of 5 days; fLMWH once or twice daily at therapeutic dose together with a VKA (target INR, 2.0-3.0) and aspirin (100 mg once daily), and continue LMWH until a stable INR has been reached but for a minimum of 5 days; gLMWH once or twice daily at therapeutic dose; and hfondaparinux weight-adjusted at a therapeutic dose.

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