Different approaches to reactivate fetal γ-globin gene expression through alteration of chromatin looping. (A) Reactivation of fetal γ-globin transcription through the introduction of an artificial transcription factor that tethers the γ-globin promoter to the LCR as previously described.6 (B) Reactivation of fetal γ-globin transcription through pharmacologic inhibition of H3K9 methyltransferases as described in Krivega et al. Professional illustration by Patrick Lane, ScEYEnce Studios.
