Clonal architecture inferred from somatic mutations observed in 10 inv(3)/t(3;3) myeloid malignancies. Distribution of estimated VAF determined from whole-exome sequencing. The width of the graph represents the density of mutations with similar VAFs. The yellow dot denotes the VAF of the 3q-aberration [(inv(3)/t(3;3)], the blue dot denotes the VAF of the RAS/RTK-associated mutation, and open circles denote the VAF of all other mutations.