MCs in the hematopoietic network. (A) Principal component analysis of 49 blood samples of the FANTOM5 data set (H9 embryonic stem cells are included for further comparison) as described in supplemental Methods. The first 3 principal components (PCs) explain 82.3% of the total variance (see supplemental Methods). (B) Means of all pairwise Pearson correlation coefficients for each sample pair as described in supplemental Methods. The mean coefficients of MCs vs other blood samples that are >0.7 are depicted in red. (C) Venn diagram with the number of genes expressed at higher level (red/green-within-red areas), and at lower level in basophils vs ex vivo MCs (cyan/green-within-cyan areas) and nondifferentially expressed RefSeq genes (purple/green-within-purple areas). The genes are specified in supplemental Table 8. The green areas denote the number of TF genes in each group. Five indicative TFs are given for each cell. (D) Significant protein class terms (α = 5%) of the differentially expressed groups.