Comparison of the DNA methylation profiles in murine leukemic and nonleukemic control cells. (A) Bar plots of the average methylation level for each CpG site (blue columns). The leukemic murine cells exhibited a distinctive hypermethylation at both regions compared with the nonleukemic counterpart. A black horizontal line indicates the 50% level of methylation. Amplicon names are indicated underneath the bar plots. Samples types are labeled on the left of each panel. The CpG island and the CTCF binding site positions are indicated with green and red bars, respectively. (B) Box plots of the methylation-level distribution in the murine samples showing hypermethylation at the CpG island and CTCF G in the leukemic cells. The P values indicate Kruskal-Wallis test results between the APL leukemic cells and the controls.