BCOR and BCORL1 truncating mutations in MDS and related disorders. (A) Localization of mutations identified in BCOR and BCORL1 genes. Each mutation is shown with an arrow. Only frameshift, nonsense, and splice site mutations are indicated. Confirmed somatic mutations are discriminated by an asterisk. The domain structures are shown in colored boxes as indicated. (B) Co-occurrence of BCOR mutations with other genes studied in 354 MDS patients (Circos Graph made on http://circos.ca/; TM, truncating mutations). The P value from Fisher’s exact test is shown, and the gene appears in red for statistically significant associations