A public BcR stereotype, as represented by the LC-MBL case 87VB. (A) VH CDR3 similarity between the LC-MBL cases 87VB and unrelated sequences. Dashes indicate identities. (B) Somatic hypermutation in the VH region of the LC-MBL case 87VB and co-clustered sequences, as visualized by using TeXshade peptide alignment tool (http://workbench.sdsc.edu/). The VH region is shown from IMGT positions 21 to 104. The letters above the line represent the amino acid changes, whereas the letters shown upside-down below the line represent the corresponding germ line amino acids of the IGHV gene. The size of the amino acid symbol represents the relative frequency of that amino acid at that position relative to all other mutations at that position in the certain IGHV group of sequences. Blank spaces represent amino acids that are unchanged in comparison with the germ line sequence.