The effects of PFT-α treatment on NHD13⁺ Tg mice.NHD13⁺ Tg mice at the MDS stage (∼ 5 months of age) were intraperitoneally injected daily with DMSO vehicle or PFT-α (2 mg/kg body weight) for 8 weeks. Peripheral blood was collected weekly. (A) The white blood cell (WBC) counts, (B) neutrophil (NE) counts, (C) lymphocyte (LY) counts, (D) hemoglobin (HB) value, (E) mean corpuscular volume (MCV), and (F) platelet counts are shown (mean ± SD, n = 5 mice/group, *P < .05). (G) Kaplan-Meier survival curves of NHD13⁺ mice treated with DMSO vehicle or PFT-α (2 mg/kg body weight) for 8 weeks (n = 5 mice/group).