Thrombosis in mice bearing HPAF-II tumors. IVC stenosis in control mice (n = 4) or tumor-bearing mice (n = 4) was induced. Three hours after the ligation, all mice were euthanized and the weight of the thrombus (in milligrams) was determined (A). IVC stenosis in control nude mice was performed. These mice were injected with PBS or the indicated doses (0.1, 0.4, and 1 ng of TF activity) of exogenous HPAF-II MPs twice at 15 minutes and 1 hour after the ligation. Blood was collected from the IVC just above the ligation site 3 hours after the ligation. Thrombus weight (B) and TAT levels (C) were measured. Saphenous vein thrombosis was induced by 10% FeCl3 in control (n = 10) and HPAF-II tumor-bearing mice (n = 12; D). Occlusion times were measured and are shown as dot plots with means. *P < .05.
