Figure 1 A limited number of major... | American Society of Hematology

Figure 1

$Figure 1. A limited number of major subsets accounts for a sizeable proportion of the CLL Ig repertoire. Nineteen different subsets were identified in the present study containing 20 or more cases and defined as major. The relative size of each major subset (no. 1, 2, etc) is indicated in the graph, while their actual member sequences are listed in supplemental Table 5. Altogether, the 19 major subsets comprised 943 rearrangements in total and accounted for ∼ 41% of the stereotypes and for ∼ 12% of the cohort sequences, hence indicating that an important fraction of CLL cases can be represented by only few VH CDR3 stereotypes.$

A limited number of major subsets accounts for a sizeable proportion of the CLL Ig repertoire. Nineteen different subsets were identified in the present study containing 20 or more cases and defined as major. The relative size of each major subset (no. 1, 2, etc) is indicated in the graph, while their actual member sequences are listed in supplemental Table 5. Altogether, the 19 major subsets comprised 943 rearrangements in total and accounted for ∼ 41% of the stereotypes and for ∼ 12% of the cohort sequences, hence indicating that an important fraction of CLL cases can be represented by only few VH CDR3 stereotypes.

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