Deficiency of GM-CSF signaling is favorable for the development of RUNX1-ETO–induced leukemia. (A) Kaplan-Meier survival curve of animals transplanted with βc^−/− cells transduced with MigR1 or MigRE. Pooled results from 4 different transplantation experiments are shown. (B) Immunoblotting analysis of spleen cells from βc^−/− MigRE leukemia animals using anti-HA tag (RUNX1-ETO) Ab. MigRE is a positive control. Wild-type (WT) is a negative control. (C) Kaplan-Meier survival curve of animals transplanted with βc^−/− or βc^+/+ cells transduced with MigR1 or MigRE. (D) Kaplan-Meier survival curve of animals transplanted with βc^−/− or βc^+/+ cells transduced with MigR1 or MigRE9a vectors.