Figure 3 Detection of normal B cells and... | American Society of Hematology

Figure 3

$Figure 3. Detection of normal B cells and BAFF levels in the peripheral blood. (A) Percentage of normal B cells of total B cells at baseline (PRE) and 12 months (n = 45). (B) Percentage of normal B cells of total B cells at baseline (Pre) and 24 months (n = 16). (C) Absolute normal B-cell count and (D) ALC in treatment-naive (○) and relapsed/refractory (♦) patients at 12 (n = 67) and 24 months (n = 38) on log10 scale. Horizontal lines denote median values. Dotted lines illustrate the normal range. (E) Box-and-whisker plot (10th-90th percentile) of serum BAFF in ibrutinib-treated patients at baseline, 6, and 12 months (n = 21) and healthy controls (n = 6). Statistical significance is indicated by **P < .01, ***P < .001, ****P < .0001, or ns (P ≥ .05). ALC, absolute lymphocyte count.$

Detection of normal B cells and BAFF levels in the peripheral blood. (A) Percentage of normal B cells of total B cells at baseline (PRE) and 12 months (n = 45). (B) Percentage of normal B cells of total B cells at baseline (Pre) and 24 months (n = 16). (C) Absolute normal B-cell count and (D) ALC in treatment-naive (○) and relapsed/refractory (♦) patients at 12 (n = 67) and 24 months (n = 38) on log₁₀ scale. Horizontal lines denote median values. Dotted lines illustrate the normal range. (E) Box-and-whisker plot (10th-90th percentile) of serum BAFF in ibrutinib-treated patients at baseline, 6, and 12 months (n = 21) and healthy controls (n = 6). Statistical significance is indicated by **P < .01, ***P < .001, ****P < .0001, or ns (P ≥ .05). ALC, absolute lymphocyte count.

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