Figure 5
Figure 5. Role of plasma VWF in platelet fibrin formation under flow. Platelets were superfused with pooled plasma from control subjects (control) or from 2 patients with VWD at shear rate of 250 s−1. Ristocetin (37.5 μg/mL) was added as indicated. Microscopic images were taken at start and after 60 seconds of fibrin formation. (A) Lag time to start of fibrin formation. (B) Quantification of OG488-fibrin(ogen) binding. Means ± SE; n = 3-4; *P < .05, ***P < .001 vs control plasma.

Role of plasma VWF in platelet fibrin formation under flow. Platelets were superfused with pooled plasma from control subjects (control) or from 2 patients with VWD at shear rate of 250 s−1. Ristocetin (37.5 μg/mL) was added as indicated. Microscopic images were taken at start and after 60 seconds of fibrin formation. (A) Lag time to start of fibrin formation. (B) Quantification of OG488-fibrin(ogen) binding. Means ± SE; n = 3-4; *P < .05, ***P < .001 vs control plasma.

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