The GFLG repeats as well as the homeodomain (HD) are essential for in vitro transformation by the NUP98/HHEX fusion gene. (A) Representative replating assay (of 3 independent experiments) of bone marrow cells transduced with NUP98/HHEX (WT) and NUP98/HHEX deletion mutants. (B) Growth curve of bone marrow cells transduced with NUP98/HHEX (WT) and NUP98/HHEX deletion mutants grown in IL-3.