Gene-expressing profiling by CESH showed clustering t(11;14)-negative and t(11;14)-positive MCLs. (A) Results of unsupervised hierarchical cluster analysis of CESH data obtained in cases 1 to 8 (MCL1-8), 4 control t(11;14)-positive MCL cases (MCL9-12), and 12 additionally included HCL cases (HCL1-12). Each row represents one hybridization experiment and each column represents an informative differentially expressed chromosomal region described in panel B. Relative overexpression and underexpression are depicted as red and green, respectively, whereas black squares represent chromosomal regions showing no differential expression. Only regions recorded in at least 25% of all cases (at least 7 of 26) are displayed in this diagram. Note a clustering of all 8 t(11;14)-negative and 4 typical MCL cases and their separation from 12 HCL cases.