Figure 1
Figure 1. Nucleotide sequence of the SLC11A1 (allele 3) promoter. Double-underlined nucleotide (G) is the putative transcription start site.44 The polypurine/polypyrimidine tract [(GT/CA)n] and Z-DNA–forming microsatellite sequence is single-underlined. The microsatellite has a z score (Z-DNA–forming potential) of 12 598.14 (z score minimum is 700), as determined with the ZHunt algorithm.45,46 HREs47,48 are in boldface. Shaded thymidine is a regulatory SNP; it was subsequently mutated to the more common cytosine SNP (T → C) simultaneously with microsatellite interchange.

Nucleotide sequence of the SLC11A1 (allele 3) promoter. Double-underlined nucleotide (G) is the putative transcription start site.44  The polypurine/polypyrimidine tract [(GT/CA)n] and Z-DNA–forming microsatellite sequence is single-underlined. The microsatellite has a z score (Z-DNA–forming potential) of 12 598.14 (z score minimum is 700), as determined with the ZHunt algorithm.45,46  HREs47,48  are in boldface. Shaded thymidine is a regulatory SNP; it was subsequently mutated to the more common cytosine SNP (T → C) simultaneously with microsatellite interchange.

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