Time course of HHV8-specific CD8 T cells in a transplant recipient with recurring KS. The figure illustrates the dynamics of HHV8 tetramer⁺ cells tested at approximately 3-month intervals over 2 years (beginning 4 years after grafting, indicated as M0), and shows major clinical events and viral load variations during the same period. × indicates gB; ▴, ORF65; ○, k12; ⋄, ORF6; and ▪, ORF61. • indicates the time course of HHV8 DNA load (copies/mL). Clinical relapses are indicated by arrows. The quadrant shows the phenotype profile and perforin expression of ORF6 tetramer⁺ cells at the indicated time.