Donor pretreatment with ProGP-1 reduces GI tract injury and inflammatory cytokine generation after SCT.

Recipient mice received transplants as in Figure 6. (A) GI tract histology was determined by semiquantitative histology as described in “Materials and methods” in recipients of control T cells (■, n = 6), G-CSF T cells (▨, n = 5), ProGP-1 T cells (▪, n = 5), or T-cell–depleted spleen (░, n = 4). (B) At 10 days after transplantation, TNFα was determined in the sera of recipients of control T cells (■, n = 7), G-CSF T cells (▨, n = 5), ProGP-1 T cells (▪, n = 5), or T-cell–depleted spleen (░, n = 3) by ELISA as described in “Materials and methods.” **P < .01 versus control B6 T.