Fig. 5.
Fig. 5. Binding mode of the dual-specific Src/Abl kinase inhibitors PP1 and CGP76030. / Phospho-Abl and Abl immunoblots of lysates from Cos7 cells transfected with pApuro, Bcr-Ablwt, or the indicated mutants of Bcr-Abl at positions 315 and 380. Cells were either left untreated or incubated with 25 μM CGP76030 or 100 μM PP1.

Binding mode of the dual-specific Src/Abl kinase inhibitors PP1 and CGP76030.

Phospho-Abl and Abl immunoblots of lysates from Cos7 cells transfected with pApuro, Bcr-Ablwt, or the indicated mutants of Bcr-Abl at positions 315 and 380. Cells were either left untreated or incubated with 25 μM CGP76030 or 100 μM PP1.

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