Model of the Fanconi anemia pathway.

The Fanconi proteins (FANCA, FANCC, FANCE, FANCF, FANCG) are required for the monoubiquitination of FANCD2. Following DNA damage, FANCD2 is monoubiquitinated and targeted to nuclear foci containing BRCA1, where it may play a role in DNA repair by homologous recombination.33 FANCD1/BRCA2 is not required for FANCD2 monoubiquitination.