Figure 1.
Figure 1. CAR structure. CAR molecules link an extracellular scFv to intracellular signaling domains. The intracellular component includes the CD3ζ intracellular signaling domain of the TCR either alone (first-generation) or in combination with 1 (second-generation) or 2 (third-generation) costimulatory domains. (Image courtesy of M. Maus.41)

CAR structure. CAR molecules link an extracellular scFv to intracellular signaling domains. The intracellular component includes the CD3ζ intracellular signaling domain of the TCR either alone (first-generation) or in combination with 1 (second-generation) or 2 (third-generation) costimulatory domains. (Image courtesy of M. Maus.41 )

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