Figure 3
Figure 3. Cell type–specific expression patterns of CIS-associated genes in lymphomas. Relative fold differences in expression levels of genes surrounding a CIS at the Zbtb7b/Adam15/Pbxip1 (A), Sh2d3c/Ttc16/Eng (B), and Gfi1/Evi5 loci (C) in MMLV-induced lymphoid tumors from Eed mutant and wild-type mice. Expression data corresponds to data in Figure 2D. Tumor IDs and phenotypes are shown at the bottom of each graph. * indicates samples with expression level differences higher than 40-fold; and + indicates MMLV retroviral insertions identified by inverse PCR. Positioning of genes and retroviral insertions (arrows with tumor ID) identified at each CIS cluster are depicted on the right panels. Chromosome number and location (in bp) for each CIS cluster are indicated at the bottom of the right panel. B indicates B220+IgM+; T DP, CD4+CD8+.

Cell type–specific expression patterns of CIS-associated genes in lymphomas. Relative fold differences in expression levels of genes surrounding a CIS at the Zbtb7b/Adam15/Pbxip1 (A), Sh2d3c/Ttc16/Eng (B), and Gfi1/Evi5 loci (C) in MMLV-induced lymphoid tumors from Eed mutant and wild-type mice. Expression data corresponds to data in Figure 2D. Tumor IDs and phenotypes are shown at the bottom of each graph. * indicates samples with expression level differences higher than 40-fold; and + indicates MMLV retroviral insertions identified by inverse PCR. Positioning of genes and retroviral insertions (arrows with tumor ID) identified at each CIS cluster are depicted on the right panels. Chromosome number and location (in bp) for each CIS cluster are indicated at the bottom of the right panel. B indicates B220+IgM+; T DP, CD4+CD8+.

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