Pts who had CE without involvement of 17p- (n=20) fared worse than those who had 17p- without CE (n=15) with a med OS of 8.2 yrs (CE) compared with 17.6 yrs (17p-) (p=0.01). However, surprisingly pts with17p- had relatively good OS in this cohort of pts with ³2 FISH tests, perhaps indicative of closer follow-up and more aggressive therapy compared with the general CLL population in previously published trials.