Iron chelators induce expression of IkB gene. 293T cells were treated with vehicle (DMSO), and iron chelators, PpYeT, PpYaT. After 24 treatment, RNA was extracted, reverse transcribed and analyzed by real-time PCR on Roche 4800 using primers for GAPDH,CDK2,CyclinA CyclinE and IkB. Primers for GAPDH were used for reference. The ΔΔCt analysis was performed using DMSO-treated, sample as a reference target and reference control. Both tested iron chelators induced expression of IkBα, the inhibitor of NFKB, suggesting potential mechanism for cyclin E deregulation. CyclinA is upregulated in PPYaT treated cells.