Figure 1.
(a) Cartoon showing structure of the mature marker/suicide gene. (b) Sort/suicide gene is co-expressed with eGFP. QBEND10 binding is compared with that of full-length CD34 (left); Similarly Rituximab binding to the marker/suicide construct is compared with that to full-length CD20 (right). (c) Killing efficiency after exposure to complement and rituximab gating on live cells shows deletion of practically all transduced T-cells.