Figure 1:
Donor Th2/Tc2R Cell Modulation of HVG Responses. B6-into-BALB/c transplantation was performed (10 x 106 donor HSC; 10 x 106 donor T cells; 1 x 106 host T cells; 1050 cGy XRT; n=10 mice per cohort). Mice were killed at d 5 post-SCT, and absolute number of host anti-donor alloreactive CD4 and CD8 Cells was determined by IFN-gamma cytokine capture flow cytometry. * indicates p<0.05 and ** indicates p<0.001 (student’s t-test); each cohort compared with cohort #2. Abbreviations: KO, Knockout, PFN, perfocin, FASL, fas ligand.
