Daunorubicin (DNR) induced accumulation of Coilin. (A) Morphology of Cajal bodies in RS4;11 or Reh in native and conditions treated with Ara c or VCR. Dose-dependent coilin accumulation was observed in RS4;11 cells (B) treated with increasing concentrations of DNR (0, 0.05 and 0.1 m g/ml) or in Reh cells (C) treated with DNR of 0, 0.02 and 0.05 mg/ml.