(A) Scatterplot of the CCA-defined methylation score and expression score summarizing the signals and correlation of 21 methylation array probe-sets and 1 expression array probe-set annotated to DNMT3B. Each point represents 1 patient. The colored barcode panels on the right and top margins of the figure represent bars at the values of the methylation score (right margin panels) and expression score (top margin panels) colored according to whether the patient experienced a pharmacologic or clinical endpoint (IVR, MRD, or EFS) that was statistically indicative of a good (blue bar) or poor (red bar) outcome. Low-, standard-, and high-risk cytogenetic subgroups are indicated by circles, triangles, and crosses, respectively. (B) EFS according to the CCA-defined methylation score for DNMT3B. (C) EFS according to the CCA-defined expression score for DNMT3B.