Neutrophil extracelluar traps (NETs) were isolated and incubated with plasma from healthy controls (A) or cirrhotic patents (B). TAT complexes were measured by ELISA. (C) TAT complexes formation of NETs were analyzed in normal plasma pre-treated with corn trypsin inhibitor (CTI ) or anti-TF in absence or presence of DNase I. (D) Calibrated automated thrombography was performed with and without 6 nM thrombomodulin (TM) in cirrhotic plasma. APC, activated protein C; de-N-Hep, de-N-sulfated heparin. *p < 0.05 vs. Control in figure A, B; *p < 0.001 vs. NETs in figure C; *p = 0.008 and ^#p = 0.039 vs. PBS in figure D.